My computer gives the best route from the North (PA, NY, MD, NJ, etc) to Asheville is I-81 South to Wythville, VA, then take I-77 South to Statesville, NC then take I-40 West to I-240 West in Asheville, NC to the Holiday Inn exit . I-81 South to Johnson City, Tn to I-181 South to Highway 23 / 19 South to I-240 West in Asheville is a good alternate if you are not in a Motorhome or pulling a trailer. Call me at 704-847-5408 if you need more information.